Sperm morphology has been proven to be the best indicator in assessing male fertility potential. The ICSI procedure was developed for cases involving male infertility. The accuracy with which the morphological changes of spermatozoa are evaluated depends on the resolution and the zoom options in the optical system used.

The high optical magnification allows for the detection of sperm anomalies - intravascular vacuoles, which could not be demonstrated by conventional methods. Microinjection of a normal-looking sperm, but with large vacuoles, reduces the incidence of pregnancies and increases early abortion.

The results of a number of studies have shown that the degree of DNA fragmentation is significantly higher in sperm with large vacuoles, and damage to sperm DNA is detrimental to the reproductive outcome. Indications for IMSI administration:

• Heavy Male Factor / Heavy Oligoasthenozoospermia or Kruger Morphology Less than 4%;
• High degree of sperm DNA fragmentation;  
• Embryos with poor morphological characteristics established in previous IVF / ICSI procedures;
• Spontaneous abortions in the first trimester of pregnancy;
• A series of failed in vitro procedures;  
• Sterility of unexplained origin;